The above video clip shows an adapted Rock Band Guitar played one-handed using the kick-pedal from the drums to strum. It's an easy modification that could just as well be applied to all the fret buttons if needed. Great for one-handed play and good too for one-switch musicians (with fast reactions) who can strum, whilst another person takes over fret work duties.
The D.I.Y. Accessible Rock Band Guitar modification can be found at the OneSwitch D.I.Y. section. You'll also find there a little guidance for hooking the guitar up to play licks and riffs on a PC courtesy of Mr. Fast Finger.